COMPOSITIONS AND METHODS FOR DETERMINING THE PROGNOSIS OF BLADDER UROTHELIAL CANCER

摘要

Described herein are compositions and methods for the prediction of bladder cancer risk of invasiveness. The compositions are microRNA molecules associated with the prognosis of bladder cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.

主权项

1. A method for determining a prognosis of bladder cancer in a human subject in need of treatment for bladder cancer, comprising:
(a) obtaining a biological sample from the subject; (b) determining in said sample the expression level the nucleic acid sequences of SEQ ID NOS: 8-10, 15, 34 and 44 and sequences at least about 90% identical thereto; and (c) comparing said obtained expression level to a threshold expression level, wherein an increase in the expression level of the nucleic acid sequences of SEQ ID NOS: 8-10 and is compared to said threshold expression level is indicative of a good prognosis and a decrease in the expression level of the nucleic acid sequence of SEQ ID NOS: 34 and 44 compared to said threshold expression level is indicative of poor prognosis for said subject; and (d) determining the prognosis of bladder cancer in the subject based on the expression level of SEQ ID NOS: 8-10, 15, 34 and 44.