HIGH-GROWTH ENTEROVIRUS 71 STRAINS AND VACCINES

摘要

The present invention relates to adapted Enterovirus 71 (EV71) vaccine strains suitable for increased vaccine production for mammals. The EV71 vaccine strains contain at least one modified enterovirus protein that results in increased production of the EV71 virus from a mammalian host cell, such as a Vero cell. The present invention also relates to the vaccines produced from the adapted EV71 virus vaccine strains, and the producing method of the vaccines.