LAYERED PHARMACEUTICAL FORMULATIONS

摘要

In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.

主权项

1. A layered pharmaceutical formulation for the administration of two or more active pharmaceutical ingredients comprising:
a first pharmaceutical layer comprising a first active pharmaceutical ingredient; a second pharmaceutical layer comprising a second active pharmaceutical ingredient; and an intermediate layer disposed between said first and said second pharmaceutical layers, wherein said intermediate layer is configured to rapidly dissolve in vivo, and thereby leave said first and said second pharmaceutical layers substantially intact but physically separated.