ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS

摘要

The present invention is directed to certain isoquinolin-l(2H)-one compounds, useful as PDEl O inhibitors, having the formula: where Rl, R2, R3, R4 and R5 are as defined herein, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDElO, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.