发明名称 |
METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF DISEASES CHARACTERIZED BY VASCULAR LEAK, HYPOTENSION, OR A PROCOAGULANT STATE |
摘要 |
Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed. |
申请公布号 |
US2016185845(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
US201414460001 |
申请日期 |
2014.08.14 |
申请人 |
Beth Israel Deaconess Medical Center, Inc. |
发明人 |
Sukhatme Vikas P.;Karumanchi S. Ananth;Parikh Samir M. |
分类号 |
C07K16/22;C12N15/113;G01N33/68;A61K31/4409;C12Q1/68;A61K38/18;A61K31/551 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Boston MA US |