发明名称 |
MULTIMERIC IMMUNOGLOBULIN-BINDING DOMAIN |
摘要 |
A multimeric immunoglobulin-binding protein having improved properties as an affinity ligand for affinity chromatography, and an insoluble support inmmobilizing such a multimer. The immunoglobulin-binding protein is represented by the formula: (R1)n-(R2)m, or (R2)m-(R1)n. R2 is an immunoglobulin-binding domain including an amino acid residue that covalently bonds to an insoluble support upon immobilization reaction with the insoluble support, and R1 is an immunoglobulin-binding domain without containing an amino acid residue the presence of which in the sequence compared to when it is absent in the sequence reduces the immunoglobulin-binding activity of the support yielded by the immobilization reaction. The immunoglobulin-binding protein satisfies: (1) n is an integer of 5 to 9; (2) m is an integer of 1 or 2; (3) the n (R1) domains may or may not have the same sequence; and (4) the total number of domains (n+m) is 6 to 10. |
申请公布号 |
US2016215027(A1) |
申请公布日期 |
2016.07.28 |
申请号 |
US201414916316 |
申请日期 |
2014.09.04 |
申请人 |
PROTENOVA CO., LTD. |
发明人 |
Majima Eiji;Shima Atsushi |
分类号 |
C07K14/31;C07K16/12;C07K1/22 |
主分类号 |
C07K14/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Higashikagawa-shi, Kagawa JP |