摘要 |
Compounds of formula (I), or salts thereof, which inhibit acetyl CoA(acet yl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, (A chemical formula should be inserted here - please see paper copy enclose d herewith) (I) wherein: R1 is selected from optionally substituted phenyl, cyclopentyl, cyclohexyl and 5- or 6-membered heteroaryl; L1 is a direct bond or a linker selected from, for example, -O-, -OCH2- and -CH2O-; R2 is selec ted from, for example, (3-6C)cycloalkyl, (5-12C)bicycloalkyl, phenyl and a 4 , 5- or 6-membered saturated, partially or fully unsaturated heterocyclyl ri ng; wherein R2 is substituted by defined substituents and R6 is selected fro m, for example, hydrogen, fluoro and chloro; together with processes for the ir preparation, pharmaceutical compositions containing them and their use as medicaments.
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