POSS-CONTAINING IN-SITU COMPOSITE NANOGEL WITH MAGNETIC RESPONSIVENESS AND METHOD FOR PREPARING THE SAME

摘要

The present invention provides a POSS-containing in-situ composite nanogel with magnetic responsiveness and the method for preparing the same, wherein POSS-containing macromolecule capable of polymerizing and metal-coordination complexing is synthetized to complex with iron salt, Fe2+/Fe3+ salts are in-situ deposited via chemical coprecipitation, and crosslinking agent and initiator are added to induce polymerization so that POSS-containing nanogel ranges with magnetic responsiveness is obtained. The present invention is of professional design, feasible technique and simple operation, and prepared nanogel magnetic particles are well dispersed with excellent magnetic responsiveness, which possesses a good application prospect in medical diagnosis, sensor, catalyst carrier and biomaterial.

主权项

1. A POSS-containing in-situ composite nanogel with magnetic responsiveness, the preparation of POSS-containing in-situ composite nanogel is that a kind of amphiphilic macromolecule (POSS-MA-PEG-DPA) which is polymerizable and capable of metal-coordination complexing adsorbs iron salts, the ferrous/ferric iron salts are in-situ precipitated via chemical coprecipitation to generate superparamagnetic Fe3O4 particles and then crosslinking agent is added for inducing polymerization to obtain stable nanogel; wherein the size of POSS-containing nanogel ranges from 100 to 300 nm, and the Fe3O4 particles with a size of 5˜15 nm are uniformly dispersed on the polymer.