发明名称 |
SOLID PHASE FOR MIXED-MODE CHROMATOGRAPHIC PURIFICATION OF PROTEINS |
摘要 |
Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix. |
申请公布号 |
US2016184813(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
US201615063235 |
申请日期 |
2016.03.07 |
申请人 |
Bio-Rad Laboratories, Inc. |
发明人 |
LIAO Jiali;OLECH Lee;CHEN Hong;HE Xuemei;FROST Russell |
分类号 |
B01J39/26;C07K1/16 |
主分类号 |
B01J39/26 |
代理机构 |
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代理人 |
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主权项 |
1. A mixed-mode chromatography medium comprising a ligand coupled to a solid support, said ligand comprising benzamidoacetic acid, said solid support having pores of a median diameter of 0.5 micron or greater with substantially no pores of 0.1 micron or less in diameter, and said ligand coupled to said solid support at a phenyl ring through a chain of one to three atoms. |
地址 |
Hercules CA US |