| 主权项 |
1. A method of inhibiting and/or decreasing the occurrence and/or severity of at least one condition selected from the group consisting of inflammation, vascular leakage, fibrosis, abnormal neovascularization, and cancer, said method comprising the step of:
administering to a subject suffering from or predisposed to the at least one condition a pharmaceutical composition, wherein the pharmaceutical composition inhibits activation of the Wnt signaling pathway, thereby inhibiting and/or decreasing the occurrence and/or severity of the at least one condition, and wherein the pharmaceutical composition comprises a monoclonal antibody or antigen binding fragment thereof and a pharmaceutically acceptable carrier, and wherein the monoclonal antibody or antigen binding fragment thereof comprises:
a heavy chain variable region CDR1 having the amino acid sequence of SEQ ID NO: 9, a heavy chain variable region CDR2 having the amino acid sequence of SEQ ID NO: 11, a heavy chain variable region CDR3 having the amino acid sequence of SEQ ID NO: 13, a light chain variable region CDR1 having the amino acid sequence of SEQ ID NO: 15, a light chain variable region CDR2 having the amino acid sequence of SEQ ID NO: 17, and a light chain variable region CDR3 having the amino acid sequence of SEQ ID NO: 19; andwherein the monoclonal antibody or antigen binding fragment thereof specifically binds to an epitope within the LRP6 extracellular domain, wherein the LRP6 extracellular domain has the amino acid sequence of SEQ ID NO: 2. |
