| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt, or solvate thereof: wherein, R1 is H, D, halogen, —CN, —C(═O)H, C1-C4alkyl, C1-C4fluoroalkyl, C3-C6cycloalkyl or C1-C4deuteroalkyl; R2 is H, halogen, —CN, —OH, NO2, NH2, N(R10)2, —OC(═O)N(R10)2, —C(═O)N(R10)2, —NHC(═O)R9, —NHC(═O)OR9, substituted or unsubstituted C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, substituted or unsubstituted C1-C4alkoxy, C1-C4fluoroalkoxy, —S—C1-C4alkyl, —S(═O)—C1-C4alkyl, —S(═O)2—C1-C4alkyl, C1-C4hydroxyalkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted monocyclic heteroaryl; R3 is H, halogen, —CN, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —S—C1-C4alkyl, —S(═O)—C1-C4alkyl, —S(═O)2—C1-C4alkyl, or C1-C4hydroxyalkyl; Ring A is a monocyclic aryl, bicyclic aryl, monocyclic heteroaryl or bicyclic heteroaryl;
each RA is independently selected from the group consisting of H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, —NR10S(═O)2R9, —C(═O)R9, —OC(═O)R9, —CO2R10, —OCO2R9, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NHC(═O)R9, —NHC(═O)OR9, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl;m is 0, 1, or 2; L1 is absent, C1-C6alkylene, C1-C6fluoroalkylene, C3-C6cycloalkylene, (C1-C6alkylene)p-C3-C6cycloalkylene-(C1-C6alkylene)q, or —(C1-C6alkylene)p-X—(C1-C6alkylene)q;
X is O, S, S(═O), S(═O)2, C(═O)NH, NHC(═O), NH, OC(═O)NH, NHC(═O)O, or NHC(═O)O;p is 0 or 1;q is 0 or 1; Q is —CO2H, —CO2(C1-C6alkyl), —OH, —CN, —B(OH)2, —C(═O)NHSO2R9, —C(═O)N(R10)2, —SO2NHC(═O)R9, —CN, tetrazolyl, —OP(═O)(OH)2, —P(═O)(OH)2 or carboxylic acid bioisostere; L2 is —C1-C6alkylene-, —C3-C6cycloalkylene-, —C(═O)—, —C(═O)—C1-C6alkylene-, —C(═O)NH—, —C(═O)NH—C1-C6alkylene-, —C(═O)O—, —C(═O)O—C1-C6alkylene-, —C1-C6alkylene-C(═O)—, —C1-C6alkylene-C(═O)NH—, —C1-C6alkylene-NHC(═O)—, —C1-C6alkylene-C(═O)O—, —C1-C6alkylene-OC(═O)—, —C1-C6alkylene-OC(═O)NH—, —C1-C6alkylene-NHC(═O)NH—, or absent; Y is H, unsubstituted or unsubstituted C1-C6alkyl, CF3, halogen, or CN; Ring B is a monocyclic aryl, bicyclic aryl, monocyclic heteroaryl or bicyclic heteroaryl;
each RB is independently selected from the group consisting of H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, —NR10S(═O)2R9, —C(═O)R9, —OC(═O)R9, —CO2R10, —OCO2R9, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NHC(═O)R9, —NHC(═O)OR9, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and a substituted or unsubstituted bicyclic heteroaryl;n is 0, 1, or 2; each R9 is independently selected from the group consisting of C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted monocyclic heteroaryl, and a substituted or unsubstituted bicyclic heteroaryl; each R10 is independently selected from the group consisting of H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, and a substituted or unsubstituted monocyclic heteroaryl; or two R10 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle. |
