METHOD FOR PRODUCING OPTICALLY ACTIVE OXINDOLE COMPOUND AND TRIAZOLIUM SALT USED THEREIN AS CATALYST

摘要

The present invention is able to provide a method for stereoselectively introducing an amino group having various substituents into the α-position of an oxindole compound by a single step by having a specific compound (a carbonyl compound such as an oxindole compound) and a specific hydroxyl amine compound or hydrogen peroxide react with each other in the presence of a specific triazolium salt and a specific trihalogenated acetonitrile compound without undergoing a reaction for reductively breaking a nitrogen-nitrogen bond, a nitrogen-oxygen bond or the like of the product. In addition, an amino group having various substituents is able to be stereoselectively introduced into the α-position of another substrate by a single step by means of a similar reaction mechanism. It is preferable that this reaction is carried out in the presence of a base.