发明名称 |
Amidoxime carboxylic acid esters of dabigatran as prodrugs and their use as medicament |
摘要 |
Substituted dabigatran compounds (I) are new. Substituted dabigatran compounds of formula (I) and their derivatives, salts, solvates, or the solvates of salts are new. R1 : H or optionally branched, optionally saturated and optionally substituted 1-12C-hydrocarbon chain; and n : 1-10. Independent claims are included for: (1) a drug comprising (I) in combination with one or more further active agents; and (2) the preparation of (I). [Image] ACTIVITY : Hemostatic; Thrombolytic; Cerebroprotective; Vasotropic; Cardiant; Antiarrhythmic; Cytostatic. MECHANISM OF ACTION : Serine protease inhibitor. |
申请公布号 |
EP2550966(B1) |
申请公布日期 |
2016.10.19 |
申请号 |
EP20110175230 |
申请日期 |
2011.07.25 |
申请人 |
DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG |
发明人 |
CLEMENT, PROF. DR. BERND;KOTTHAUS, DR. JOSCHA;KOTTHAUS, JÜRKE;SCHADE, DENNIS DR. |
分类号 |
A61K31/4439;A61P7/02;C07D401/12 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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