发明名称 |
Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics |
摘要 |
The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX(TM) method with 2'-O-methyl substituted nucleic acids, and cell surface SELEX(TM) are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
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申请公布号 |
US2009105172(A1) |
申请公布日期 |
2009.04.23 |
申请号 |
US20060885908 |
申请日期 |
2006.03.07 |
申请人 |
DIENER JOHN L;HATALA PAUL;KILLOUGH JASON R;WAGNER-WHYTE JESS;WILSON CHARLES;ZHU SHUHAO |
发明人 |
DIENER JOHN L.;HATALA PAUL;KILLOUGH JASON R.;WAGNER-WHYTE JESS;WILSON CHARLES;ZHU SHUHAO |
分类号 |
A61K31/7088;A61P43/00;C07H21/00;C12Q1/68 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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