发明名称 |
13,13A-DIHYDROBERBERINE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITION AND USE |
摘要 |
The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
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申请公布号 |
EP2070926(A1) |
申请公布日期 |
2009.06.17 |
申请号 |
EP20070816496 |
申请日期 |
2007.09.30 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
HU, LIHONG;YE, JIMING;LI, JINGYA;JAMES, DAVID, E;KRAEGEN, EDWARD, W;ZHANG, HANKUN;CHENG, ZHE;LI, JIA |
分类号 |
C07D455/03;A61K31/4375;A61P3/04;A61P3/06;A61P3/10 |
主分类号 |
C07D455/03 |
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