| 摘要 |
Peptides and peptide derivatives of the following general Formula I:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ H 2 N-GHRPX 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 PX 9 X 10 X 11 PX 12 PPPX 13 X 14 X 15 X 16 GYR-X 17 €ƒ€ƒ€ƒ€ƒ€ƒ(I),
wherein:
X 1 - X 16
denote one of the 20 genetically encoded amino acids,
X 17
denotes OR 1 , with R 1 = hydrogen or (C 1 - C 10 - alkyl), or NR 2 R 3 , R 2 and R 3 being identical or different and denoting hydrogen, (C 1 - C 10 ) - alkyl, or a residue -PEG 5-60K , wherein the PEG-residue is linked to the N atom via a spacer, or a residue NH-Y-Z-PEG 5-60K , wherein Y denotes a chemical bond or a genetically coded amino acid from among the group of S, C, K or R, and Z denotes a spacer by way of which a polyethylene glycol (PEG)-residue may be linked,
as well as the physiologically acceptable salts thereof,
or wherein:
X 15 or X 16
denotes an amino acid from the group of C or K, which is linked to a residue Z- PEG 5-60K via the heteroatom in the side chain, and wherein
X 17
denotes OR 1 , with R 1 = hydrogen or (C 1 -C 10 - alkyl), or NR 2 R 3 , R 2 and R 3 being identical or different and denoting hydrogen or (C 1 - C 10 )- alkyl,
as well as the physiologically acceptable salts thereof. |
