发明名称 |
ANTIBODY-UREASE CONJUGATES FOR THERAPEUTIC PURPOSES |
摘要 |
Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity. |
申请公布号 |
WO2016116907(A1) |
申请公布日期 |
2016.07.28 |
申请号 |
WO2016IB50342 |
申请日期 |
2016.01.22 |
申请人 |
HELIX BIOPHARMA CORPORATION |
发明人 |
CHAO, HEMAN;WONG, WAH YAU;TIAN, BAOMIN;GASPAR, KIMBERLY JAYNE;KUMAR, PRAVEEN |
分类号 |
A61K47/48;A61P35/00;C07K16/30;C07K19/00;C12N9/80;C12N9/96 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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