Process for preparing benzisothiazolinones

摘要

N-alkylated 1,2-benzisothiazolin-3-ones can be prepared in good yield and good selectivity by reaction of the lithium salt of 1,2-benzisothiazolin-3-one with an electrophilic alkylating agent.

主权项

1. A method of making an N-substituted 1,2-benzisothiazolin-3-one comprising reacting the lithium salt of 1,2-benzisothiazolin-3-one with a compound of formula R—X where R is C1-C8 straight chain or branched alkyl or benzyl and X is selected from the group consisting of Cl, Br, I, SO3Me, triflate, mesyl, tosyl, besyl and sulfonate which may be substituted by one or more F atoms.