发明名称 Antagonists of IL-6 to prevent or treat thrombosis
摘要 Abstract The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.
申请公布号 AU2016256810(A1) 申请公布日期 2016.12.01
申请号 AU20160256810 申请日期 2016.11.11
申请人 Alder Biopharmaceuticals, Inc. 发明人 Smith, Jeffrey T. L.
分类号 C07K16/24;A61K39/00;A61K39/395;A61K49/00;A61K51/00;A61P35/00;C07H21/04;C12N1/19;C12N15/63;C12P21/08 主分类号 C07K16/24
代理机构 代理人
主权项
地址