发明名称 |
Antagonists of IL-6 to prevent or treat thrombosis |
摘要 |
Abstract The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al. |
申请公布号 |
AU2016256810(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
AU20160256810 |
申请日期 |
2016.11.11 |
申请人 |
Alder Biopharmaceuticals, Inc. |
发明人 |
Smith, Jeffrey T. L. |
分类号 |
C07K16/24;A61K39/00;A61K39/395;A61K49/00;A61K51/00;A61P35/00;C07H21/04;C12N1/19;C12N15/63;C12P21/08 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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