METHOD FOR MODULATING, REGULATING AND/OR STABILIZING ANGIOGENESIS

摘要

A method of modulating, regulating and/or stabilizing angiogenesis in a mammal in which an active PDGF-D or a polynucleotide encoding an active PDGF-D is administered to the mammal. The PDGF-D is advantageously co-adminstered with an angiogenic growth factor, such as a member of the VEGF family of growth factors. The claimed method inhibits leakage of blood vessels and is useful, inter alia, for treatment of edemas.