摘要 |
The invention provides novel compounds having the general formula:;;wherein R1, R2, R3, R4, R5, W and X are as described herein, compositions including the compounds and methods of using the compounds. |
主权项 |
1. Compounds of formula (I)wherein
W is nitrogen or —CR9, wherein R9 is halogen; X is nitrogen or —CR10, provided that when X is —CR10, R1 is hydrogen, R2 is halogen, R3 is hydrogen, wherein R10 is C1-6alkylsulfonylphenyl; when X is nitrogen, R1 is halogen, R2 is hydrogen, R3 is R4 and R5, with the carbon atom to which they are attached, form cycloalkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, aminocarbonyl, C1-6 alkoxycarbonyl-CyH2y—, C1-6 alkylcarbonyl, C1-6alkylsulfonyl, carboxy or cyano, wherein y is 0-6; R8 is C1-6alkylsulfonyl, C1-6alkoxy, cyano or hydroxy;or pharmaceutically acceptable salts thereof. |