发明名称 |
SIGNALLING SYSTEM |
摘要 |
The present invention relates to a chimeric antigen-receptor (CAR) signalling system comprising; (i) a targeting component comprising an antigen-binding domain, a transmembrane domain and a first heterodimerization domain; and (ii) an intracellular signalling component comprising a signalling domain and a second heterodimerization domain; wherein spontaneous heterodimerization between the first and second heterodimerization domains causes the targeting component and signalling component to form a functional CAR complex. |
申请公布号 |
WO2016124930(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
WO2016GB50257 |
申请日期 |
2016.02.04 |
申请人 |
UCL BUSINESS PLC |
发明人 |
PULÉ, MARTIN;CORDOBA, SHAUN |
分类号 |
C07K14/705;A61K35/17;C12N5/16 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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