PATIENT-SPECIFIC IMMUNOTHERAPY FOR TREATING HETEROGENEOUS TUMORS

摘要

In the field of therapy, specifically patient-specific immune therapy for cancer, improved therapeutic modalities are provided for. The identity and dosage of the administered anti-tumor antibodies is determined and dynamically adjusted to the individual patient's condition, disease and/or treatment progression, thus providing anti-cancer treatment which may be particularly advantageous for the treatment of heterogeneous tumors.

主权项

1. A method of adaptively producing a pharmaceutical composition for the treatment of a disease in a patient in need thereof, comprising:
determining a model including: a current disease state corresponding to the disease of the patient, and pharmaceutical components having treatment effects on the disease state based on their measured partitioning among factors of the disease state; calculating a composition of said pharmaceutical components acting on the current disease state to produce a target disease state; formulating a treatment composition for said patient based on the calculated composition; and adjusting the model based on differences between the target disease state and a new disease state of the patient after administration of said formulation; and repeating said calculating and formulating.