| 主权项 |
1. A metal free process for the synthesis of phenol compound of Formula I, Wherein, R is selected from CHO, COR3. COOR4. COOH, CN, NO2, Ts, Nitroethene, α,β-unsaturated ketone, α,β-unsaturated ester; R1 is selected from halides, particularly Cl, Br or I or phenyl or p-F-Ph; R2 is selected from H or alkyl, preferably methyl, tertiary butyl or phenyl; R3 is selected from alkyl, allyl or phenyl; R4 is selected from alkyl, allyl or benzyl; and ketone compound of Formula II, Wherein, R, R1, R2, R3 and R4 are as above; , from substituted cyclohexenes of formula III, Wherein, R, R1, R2, R3 and R4 are as above; comprising: a. Mixing the substrate and solvent and optionally a base, with continuous bubbling of air at 50 to 100° C. for 5 to 60 hours and b. Extracting the product of step (a) and c. purifying the product of step (b) to obtain the substantially pure desired product. |
