发明名称 |
GENETICALLY MODIFIED MESENCHYMAL STEM CELLS EXPRESSING ALPHA-1 ANTITRYPSIN (AAT) |
摘要 |
The invention relates to genetically modified mesenchymal stem cell for use as a medicament in the treatment of medical conditions associated with inflammation and/or an unwanted immune response in subjects without an alpha1-antitrypsin (AAT) deficiency, wherein said stem cells comprise an exogenous nucleic acid comprising (i) an Alpha-1 antitrypsin (AAT) encoding region operably linked to (ii) a promoter or promoter/enhancer combination. |
申请公布号 |
WO2016110565(A1) |
申请公布日期 |
2016.07.14 |
申请号 |
WO2016EP50271 |
申请日期 |
2016.01.08 |
申请人 |
APCETH GMBH & CO. KG |
发明人 |
GÜNTHER, CHRISTINE;GEIGER-SCHREDELSEKER, SABINE;HERMANN, FELIX;HUSS, RALF;FORSTER, DARIA LARISSA |
分类号 |
C12N5/0775;A61K35/12 |
主分类号 |
C12N5/0775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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