发明名称 |
Method of extended culture of antigen-specific cyotoxic T lymphocytes |
摘要 |
<p>The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.</p> |
申请公布号 |
EP2070542(A2) |
申请公布日期 |
2009.06.17 |
申请号 |
EP20090004189 |
申请日期 |
2002.08.15 |
申请人 |
TAKARA BIO INC. |
发明人 |
SAGAWA, HIROAKI;IDENO, MITSUKO;KATO, IKUNOSHIN |
分类号 |
A61K35/14;A61K39/395;A61P31/12;A61P31/22;A61P35/00;A61P37/04;C07K14/78;C12N5/02;C12N5/07;C12N5/0783;C12N15/09 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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