Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

摘要

Compounds that inhibit PI3K´ activity, including compounds that selectively inhibit PI3K´ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K´) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K´ plays a role in leukocyte function, using the compounds also are disclosed.