| 摘要 |
N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for treating disorders and condition associated with the nervous system or musculoskeletal system, such as pain, weakness, numbness, arthritis, joint inflammation, weakness of muscles or joints, and myopia. |
| 主权项 |
1. A method of treating a disorder or condition selected from the group consisting of pain, weakness, numbness, arthritis, joint inflammation, weakness of muscles or joints, and myopia in a subject in need thereof, the method comprising topically or systemically administering to the subject a composition comprising a therapeutically effective amount of a dipeptide derivative of formula (I):
R1-AAB-AAC-R2 (I) or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier, wherein R1 is an acyl radical having up to 9 carbon atoms; AAB is tyrosine and AAC is tyrosine, or AAB is valine and AAC is alanine; R2 is OR3, NHR4, or NHNHR5; R3 is H, or an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms; and R4 and R5 are independently H, OH, or an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms. |
