METHOD FOR SOLID-PHASE SYNTHESIS OF DNA-ENCODED CHEMICAL LIBRARY

摘要

Provided is a method for solid-phase synthesis of a DNA-encoded chemical library, the method comprising the steps of: a) reacting a solid-phase carrier G-1 with a linker molecule L-1 to prepare L-G-1; b) reacting DNA with a linker molecule L-0 to prepare L-2; c) reacting L-G-1 with L-2 to prepare L-G-2; d) removing a protecting group from L-G-2 to obtain L-G-2-1; e) reacting with a building block and performing DNA encoding; f) removing the solid-phase carrier to obtain a DNA-encoded chemical library.