| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Q1 is N or CR1, Q2 is N or CR2, R1, R2, R4 and R5 are each independently H, halogen, CN, OH, NH2, C1-3 alkyl optionally substituted by one or more F, C3-7 cycloalkyloxy optionally substituted by one or more F, or C1-3 alkoxy optionally substituted by one or more F, R3 is H, halogen, CN, C1-4 alkyl optionally substituted by one or more F, C1-4 alkoxy optionally substituted by one or more F, C3-7 cycloalkyloxy optionally substituted by one or more F, or C1-4 alkylthio optionally substituted by one or more F, With the proviso that at least 2 of R1, R2, R3, R4 and R5 are H, Y is O, CH2O or OCH2 R6 and R7 can be attached at any point on the ring and are independently H, F, CN, OH, NH2, C1-3 alkyl optionally substituted by one or more F, or C1-3 alkoxy optionally substituted by one or more F, or R6 and R7 can be taken together, with the atoms to which they are attached, to form a 3- to 7-membered cycloalkane ring, X is CR101 or N, R101 is H or C1-3 alkyl, Z is CH2, CH(CH3), NH or O, A is C(O)NR103R104, R103 and R104 are each independently selected from H, (C1-6 alkyl optionally substituted by OH, C1-6 alkoxy, CN or by one or more F), and (C3-7 cycloalkyl optionally substituted by OH, C1-6 alkoxy or by one or more F). |
