| 摘要 |
A method for inhibiting, reducing, or preventing antinociceptive/analgesic tolerance in a subject associated with the continued administration of opiates. Specifically, the method provides for administering agents, which reduce or prevent the increase in ceramide levels caused by administration of an opiate in a human or non-human subject. The method allows for improved pain management in subjects suffering from chronic pain and disorders associated with long term administration of opiates.
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