DIAGNOSTIC TUMOR MARKERS, DRUG SCREENING FOR TUMORIGENESIS INHIBITION, AND COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

摘要

PROBLEM TO BE SOLVED: To provide a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, particularly cancer.SOLUTION: Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. The present invention includes: elucidating critical aspects of a mechanism by which MUC1 triggers cell proliferation and tumorigenesis; providing novel molecular targets for drug screening assays; and identifying compounds that inhibit the MUC1-dependent tumorigenesis using the assays. These enable an early diagnostic assay.