SOLUBLE HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES AND APPLICATIONS THEREOF

摘要

The disclosure provides novel forms of tau species and applications thereof, as well as methods of diagnosing and/or treating tau-associated neurodegeneration. the inventors have shown that tau-null neurons lacked activation of AP-induced mitochondrial intrinsic caspase cascades in the neurons and were subsequently protected from A3-induced dendritic spine loss and neurodegeneration. Accordingly, embodiments of various aspects described herein relate to compositions comprising soluble HMW tau species that is responsible for inter-neuron propagation and applications thereof. Methods of treating and diagnosing tau-associated neurodegeneration in a subject are also provided herein.

主权项

1. A composition comprising soluble high molecular weight (HMW) tau species, wherein the soluble HMW tau species is non-fibrillar, with a molecular weight of at least about 500 kDa, and wherein the composition is substantially free of soluble low molecular weight (LMW) tau species.