3-ARYL-4H-CHROMENE-4-ONES AS ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER

摘要

Isoflavonoids or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof for the treatment of prostate cancer or for the treatment or inhibition of prostate cancer metastasis in a patient in need thereof are disclosed.

主权项

1. A compound having formula (I) or pharmaceutically acceptable salt thereof: wherein Ar is aryl; n is an integer from 1 to 5; each X is independently a halide, or alkoxy, or more than one X on Ar together form a cyclic ether structure; and wherein the compound is substituted on the C-2 position with H, alkyl, cycloalkyl or alkoxy, substituted on the C-5, C-6, and C-7 positions independently with H, hydroxy (OH), alkyl, cycloalkyl, alkoxy, acetyl, ester, acetoxy, substituted on the C-8 position with hydroxy (OH), alkyl, cycloalkyl, alkoxy, acetyl, ester, acetoxy, CH2OY1 where Y1 is hydrogen, alkyl, acetyl or the substituents on either C-6 and C-7 or the substituents on C-7 and C-8 together form a substituted or unsubstituted, saturated or unsaturated, cyclic or polycyclic ring structure which includes at least one chalcogen, wherein the alkyl, cycloalkyl, and alkoxy substituents can be substituted with one or more of a hydroxy, ester, acetoxy, alkoxy, or carbonyl.