发明名称 |
LIVE VACCINE STRAINS OF FRANCISELLA |
摘要 |
A strain of Francisella species wherein a gene which encodes for part of the glutamate metabolic pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Particularly effective strains include those where the capB gene is deleted. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein a gene which encodes for another component of the cell is also inactivated. Pharmaceutical compositions comprising said strains, together with methods which utilise such strains are also described and claimed.
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申请公布号 |
US2010021501(A1) |
申请公布日期 |
2010.01.28 |
申请号 |
US20070374888 |
申请日期 |
2007.07.25 |
申请人 |
MICHELL STEPHEN LLOYD;OYSTON PETRA CLAIRE FARGUHAR;TITBALL RICHARD WILLIAM |
发明人 |
MITCHELL STEPHEN LLOYD;OYSTON PETRA CLAIRE FARGUHAR;TITBALL RICHARD WILLIAM |
分类号 |
A61K39/02;A61P31/04;C12N1/20 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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