| 发明名称 |
COMPOSITIONS AND METHODS FOR INCREASING MESENCHYMAL STROMAL CELL MIGRATION TO TUMORS |
| 摘要 |
The present application is directed to compositions and methods for treating a subject with cancer and/or increasing migration of a mesenchymal stromal cells (MSCs) stimulated with a recombinant autocrine motility factor (rAMF) to a tumor or a tumor cell, e.g. hepatocellular carcinoma (HCC). In addition, methods for increasing adhesion of MSCs to endothelial cells with rAMF are disclosed. In some embodiments, the MSCs comprise a therapeutic agent, e.g., an anti-tumor agent. |
| 申请公布号 |
US2016220612(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201414916963 |
申请日期 |
2014.09.05 |
| 申请人 |
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) ;ASOCIACION CIVIL DE ESTUDIOS SUPERIORES ;INIS BIOTECH LLC |
发明人 |
MAZZOLINI Guillermo Daniel;GARCIA Mariana Gabriela;BAYO Juan |
| 分类号 |
A61K35/28;C12N5/077 |
主分类号 |
A61K35/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a mesenchymal stromal cell (MSC) stimulated with a recombinant autocrine motility factor (rAMF), wherein the MSC comprises a therapeutic agent and wherein the MSC of the composition has (1) increased migration to a tumor or a tumor cell after rAMF stimulation and/or (2) increased adhesion to an endothelial cell after rAMF stimulation. |
| 地址 |
Buenos Aires AR |
