COMBINATION THERAPIES FOR TREATING CANCERS

摘要

Provided herein are methods that relate to a therapeutic strategy for treatment of cancer, including hematological malignancies. In particular, the methods include administration entospletinib and a Bcl-2 inhibitor, such as venetoclax, navitoclax, and ABT-737.

主权项

1. A method for treating cancer in a human in need thereof, comprising administering to the human a therapeutically effective amount of a Syk inhibitor and a therapeutically effective amount of a Bcl-2 inhibitor, wherein:
the Syk inhibitor is a compound of formula A1: or a pharmaceutically acceptable salt or hydrate thereof; and the Bcl-2 inhibitor is selected from the group a compound of Formula B1, a compound of Formula B2, and a compound of Formula B3: or a pharmaceutically acceptable salt thereof.