| 发明名称 |
Piperazine Derivatives As Glyt 1 Inhibitors |
| 摘要 |
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R<SUP>1</SUP>, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
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| 申请公布号 |
US2008090822(A1) |
申请公布日期 |
2008.04.17 |
| 申请号 |
US20060908149 |
申请日期 |
2006.03.09 |
| 申请人 |
GLAXO GROUP LIMITED |
发明人 |
BRADLEY DANIEL M.;BRANCH CLIVE L.;BROWN BETHANY J.;CHAN WAI N.;COULTON STEVEN;GILPIN MARTIN L.;GOUGH SHARON L.;MACRITCHIE JACQUELINE A.;MARSHALL HOWARD R.;NASH DAVID J.;PORTER RODERICK A.;DEAN ANTHONY W.;DOYLE PAUL M.;EVANS BRIAN;STASI LUIGI P. |
| 分类号 |
A61K31/535;A61K31/497;A61P25/18;C07D213/75;C07D213/85;C07D215/38;C07D239/42;C07D241/44;C07D295/192;C07D401/02;C07D401/14;C07D487/04 |
主分类号 |
A61K31/535 |
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