DEHYDROABIETIC ACID (DHAA) DERIVATIVES FOR USE AS ION CHANNEL OPENERS

摘要

The present invention relates to derivatives of dehydroabietic acid useful in treatment ofcardiac arrhythmiaor a hyperexcitablity disease, such as epilepsy or pain, by extracellularly acting on the voltage sensitive domain (VSD) to open atleast one member of the family of voltage-gated Kv (potassium) channels.