发明名称 |
CHEMICALLY MODIFIED SMALL MOLECULES |
摘要 |
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition, A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer. |
申请公布号 |
AU2014280956(B2) |
申请公布日期 |
2016.09.22 |
申请号 |
AU20140280956 |
申请日期 |
2014.12.24 |
申请人 |
Nektar Therapeutics |
发明人 |
BENTLEY, Michael D.;VIEGAS, Tacey X.;GOODIN, Richard R.;CHENG, Lin;ZHAO, Xuan |
分类号 |
A61K47/48;C08G65/08;C08G65/333 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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