发明名称 |
METHODS AND COMPOSITIONS FOR MODIFYING ENDOTHELIAL CELLS |
摘要 |
The present invention includes methods and compositions for modifying endothelial cells for improved vascular self-assembly. In some embodiments, the invention includes a modified endothelial cell and methods of generating and using the modified endothelial cell in a pharmaceutical composition. Other embodiments include methods of promoting vascular self-assembly and regenerating vascular structures in a subject in need thereof. In particular, the modified endothelial cell has reduced immunogenicity in an allogeneic environment in the subject, while still capable of forming vascular structures. |
申请公布号 |
WO2016154176(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016US23523 |
申请日期 |
2016.03.22 |
申请人 |
YALE UNIVERSITY |
发明人 |
POBER, Jordan;ABRAHIMI, Parwiz |
分类号 |
A61K48/00;C12N15/113;C12N15/63;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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