| 摘要 |
PROBLEM TO BE SOLVED: To provide tissue products from animals lacking functional α1,3 galactosyl transferase.SOLUTION: The present invention provides tissues derived from animals, which lack any expression of functional α1,3 galactosyl transferase (α-1,3.GT). Such tissues can be used in the field of xenotransplantation, such as orthopedic reconstruction and repair, skin repair and internal tissue repair or as medical devices. The animal can be a ruminant or an ungulate, such as a bovine, porcine or ovine. The tissues from animals lacking any functional expression of the α-l,3-GT gene can be obtained from a prenatal, neonatal, immature, or fully mature animal, such as a porcine, bovine or ovine.SELECTED DRAWING: None |
