FAB FRAGMENT SPECIFICALLY BINDING TO EGFR

摘要

The present invention relates to: a fragment antigen-binding (Fab) fragment specifically binding to an epidermal growth factor receptor (EGFR); an expression construct for preparing the Fab fragment; a method for preparing the Fab fragment; and a pharmaceutical composition containing the Fab fragment. Since the Fab fragment specifically binding to an EGFR is small compared to an antibody, the Fab fragment has a good infiltration rate for tissues or tumors and can be prepared in bacteria, thereby lowering production costs. In addition, the Fab fragment specifically binding to an EGFR provides an increased in vivo half-life through PEGylation.