Rotationally actuated magnetic bead trap and mixer

摘要

A magnetic bead trap-and-mixer includes a channel having openings at opposing ends, and a rotor adjacent to the channel and comprising a permanent magnet, wherein the rotor is adapted to apply a magnetic field to the channel of sufficient strength to direct the movement of magnetic beads therein. In aspects, the channel is straight and/or has narrowed end. In further aspects, the rotor generates in the channel areas of areas of strong magnetic fields alternating with areas of very weak magnetic fields and the strong magnetic fields extend entirely across the channel.

主权项

1. A magnetic bead trap-and-mixer comprising:
a straight channel having openings at opposing ends, and a rotor adjacent to the channel and comprising a permanent magnet, wherein the rotor is adapted to apply a magnetic field to the channel of sufficient strength to direct the movement of magnetic beads therein, wherein the magnetic field extends entirely across the channel, and wherein said movement is both across the channel and longitudinally upstream or downstream wherein the rotor has a plane of rotation that is tilted or adjustable with respect to an axis of the channel, and wherein said rotor comprises magnets positioned in a rotating disc.