| 发明名称 |
ANTI-VIRUS COMPOUND |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound that is effective in inhibiting the function of non-structural protein NS5A which is an essential component in the replication of C type hepatitis virus ("HCV").SOLUTION: Provided is a compound exemplified by methyl{(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piperidine-1-yl]phenyl}-5-(6-fluoro-2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl}-1H-benzimidazole-5-yl) pyrrolidin-2-yl]-6-fluoro-1H-benzimidazole-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutanoic-2-yl}carbamate or the like, or a pharmaceutically acceptable salt thereof and a derivative thereof.SELECTED DRAWING: None |
| 申请公布号 |
JP2016106075(A) |
申请公布日期 |
2016.06.16 |
| 申请号 |
JP20150212539 |
申请日期 |
2015.10.29 |
| 申请人 |
ABBVIE BAHAMAS LTD |
发明人 |
DEGOEY DAVID A;KATI WARREN M;CHARLES W HUTCHINS;DONNER PAMELA L;ALLAN C KRUEGER;RANDOLPH JOHN T;MOTTER CHRISTOPHER E;NELSON LISSA T;SACHIN V PATEL;MATULENKO MARK A;KEDDY RYAN G;TAMMIE K JINKERSON;GAO YI;LIU DACHUN;PRATT JOHN K;ROCKWAY TODD W;MARING CLARENCE J;HUTCHINSON DOUGLAS K;FLENTGE CHARLES A;WAGNER ROLF;TUFANO MICHAEL D;BETEBENNER DAVID A;SARRIS KATHY;KEVIN R WOLLER;WAGAW SABLE H;JEAN C CALIFANO;LI WENKE;DANIEL D CASPI;BELLIZZI MARY E;WILLIAM A CARROLL |
| 分类号 |
C07D401/14;A61K31/4184;A61K31/422;A61K31/438;A61K31/4439;A61K31/454;A61K31/496;A61K31/506;A61K31/5377;A61K38/00;A61P1/16;A61P31/12;C07C271/22;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D453/06;C07D491/113;C07F5/02;C07F9/568 |
主分类号 |
C07D401/14 |
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