发明名称 |
DRUG RELEASING COATINGS FOR BALLOON CATHETERS |
摘要 |
Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups. |
申请公布号 |
US2016250453(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
US201615154669 |
申请日期 |
2016.05.13 |
申请人 |
Lutonix, Inc. |
发明人 |
Wang Lixiao |
分类号 |
A61M25/10;A61K31/436;A61K31/337;A61L29/16;A61L29/08 |
主分类号 |
A61M25/10 |
代理机构 |
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代理人 |
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主权项 |
1. A balloon catheter for delivering a therapeutic agent to a blood vessel while the balloon catheter is deployed at a target site of the blood vessel, the balloon catheter comprising:
an elongate member having a lumen and a distal end, an expandable balloon attached to the distal end of the elongate member and in fluidic communication with the lumen; and a dried coating layer overlying an exterior surface of the expandable balloon, wherein: the dried coating layer comprises a total drug load of a hydrophobic therapeutic agent and a combination of additives comprising a first additive and a second additive; the hydrophobic therapeutic agent is one of paclitaxel, rapamycin, or combinations thereof; the first additive is one of PEG sorbitan monolaurates, PEG sorbitan monooleates, or combinations thereof; and the second additive is one of sorbitol, sorbitan, xylitol, gluconolactone, lactobionic acid, or combinations thereof. |
地址 |
New Hope MN US |