摘要 |
Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed. |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
BOXER, Matthew Brian;ROHDE, Jason Matthew;PRAGANI, Rajan;LIU, Li;DAVIS, Mindy Irene Emily;BRIMACOMBE, Kyle Ryan;SHEN, Min;SIMEONOV, Anton;KARAVADHI, Surendra;URBAN, Daniel Jason;JADHAV, Ajit;WANG, Xiaodong;MCIVER, Andrew Louis |