| 发明名称 |
COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE |
| 摘要 |
The present invention relates to combinations comprising a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A (“SV2A”) ligand. |
| 申请公布号 |
US2016367554(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201515112818 |
申请日期 |
2015.01.20 |
| 申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
KLEIN Brian D;LAVREYSEN Hilde;PYPE Stefan Maria, Christiaan;TWYMAN Roy E.;VAN OSSELAER Nancy Eulalie, Sylvain;WHITE H. Steven;CEUSTERS Marc André;CID-NÚÑEZ José Maria;TRABANCO-SUÁREZ Andrés Avelino;BONE Roger Francis |
| 分类号 |
A61K31/506;A61K31/4545;A61K31/437;A61K31/496;A61K31/4015;A61K31/381 |
主分类号 |
A61K31/506 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A combination comprising
(a) a synaptic vesicle protein 2A (“SV2A”) ligand; and (b) a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) compound or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof. |
| 地址 |
Beerse BE |
