| 主权项 |
1. A method for treating a bacterial infection in a mammal comprising administering to the mammal an effective amount of a compound of formula (I):wherein:
each R1 is independently selected from hydrogen, halo, cyano, nitro, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, aryl, heteroaryl, heterocycle, and NReRf, wherein each (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (Cr C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, aryl, heteroaryl, and heterocycle is optionally substituted with one or more groups independently selected from halo, cyano, nitro, NReRf, —CRg(═N)N(Rg)2, —NRgC(═N)—N(Rg)2, —NRg—C(═NRg)Rg, (C1-C3)alkyl, (C1-C3)alkoxy, (C1-C3)alkanoyl, (C1-C3)alkoxycarbonyl, (C1-C3)alkanoyloxy, aryl, heteroaryl, and heterocycle; R2 is H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from —ORk, halo, NReRf, NReRf, —CRg(═N)N(Rg)2, —NRgC(═N)—N(Rg)2, and —NRg—C(═NRg)Rg; R3 is:which is optionally substituted with one or more groups independently selected from trifluoromethyl, pentafluoroethyl, or 1-(trifluoromethyl)cyclopropyl;
W is —NHCORa, —N(CORa)(CORb), —NRaCH2ORa, —NHC(═O)ORa, —NHC(═O)NRaRb, or —N(Ra)SOmRd; each Ra is independently selected from H, aryl, heteroaryl, heterocycle, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxy, halo, cyano, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, —NReRf, —CRg(═N)N(Rg)2, —NRgC(═N)—N(Rg)2, —NRg—C(═NRg)Rg and heterocycle; wherein any aryl, heteroaryl, heterocycle, and (C3-C8)cycloalkyl(C1-C6)alkyl of Ra is optionally substituted with one or more groups independently selected from hydroxy, halo, cyano, trifluoromethoxy, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, —NReRf, —CRg(═N)N(Rg)2, —NRgC(═N)—N(Rg)2, —NRg—C(═NRg)Rg, and (C1-C6)alkoxycarbonyl; each Rb is independently selected from H and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxy, halo, cyano, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, —NReRf, —CRg(═N)N(Rg)2, —NRgC(═N)—N(Rg)2, —NRg—C(═NRg)Rg, and heterocycle; each Rd is independently selected from OH, —NH2, —NReRf, aryl, heteroaryl, heterocycle, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxy, halo, cyano, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, —NReRf, —CH(═N)NH2, —NHC(═N)—NH2, —NH—C(═NH)R, and heterocycle; each Re is independently selected from H, aryl, heteroaryl, heterocycle, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxy, halo, cyano, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, and heterocycle; and each Rf is independently selected from H and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxyl, halo, cyano, (C1-C6)alkoxycarbonyl, aryl, heteroaryl, and heterocycle; or Re and Rf together with the nitrogen to which they are attached form a aziridino, azetidino, morpholino, piperazino, pyrrolidino or piperidino; each Rg is independently selected from H and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from halo; each Rk is independently selected from H or (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from hydroxy, halo, oxo, carboxy, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy; m is 0, 1, or 2; and n is 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof. |
