Influenza vaccine, composition, and methods of use

摘要

The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.

主权项

1. A method of lessening the severity of lung immunopathology due to infection with influenza A virus in a mammalian subject who is at increased risk of developing the infection, said method comprising the step of administering to the subject a sufficient amount of a live attenuated, mutated Bordetella pertussis strain, wherein the strain comprises a mutated pertussis toxin(ptx) gene, a deleted or mutated dermonecrotic (dnt) gene, and a heterologous ampG gene, and wherein the method elicits an immune response that lessens the severity of the influenza A-induced lung immunopathology in the subject, upon infection with the influenza A virus.